Comparison of Pretransplant Donor Kidney GFR with 3-month Posttransplant GFR in Donor and Recipient by DTPA Scan
Year: 2025
Type: article
Abstract: Although compensatory hyperfiltration is usually well tolerated, evidence from long-term follow-up studies indicates that kidney donors may have a higher risk of developing hypertension and microalbuminuria.Hence, systematic monitoring of both donors and recipients is vital for early recognition of functional decline and prompt management. IntroductIonChronic kidney disease (CKD) represents a progressive and irreversible loss of renal function, usually developing insidiously over months to years.In its early phases, individuals may remain symptom-free, with subtle abnormalities such as proteinuria or a mild rise in serum creatinine being the only signs.1,2 As the disease advances, clinical complications such as hypertension, azotemia, anemia, pulmonary oedema, metabolic bone disease, and uremia become increasingly apparent.Once the glomerular filtration rate (GFR) declines below 15 mL/ min, the condition is classified as end-stage renal disease (ESRD).At this point, renal replacement therapy in the form of dialysis or kidney transplantation becomes necessary.3 Transplantation is generally preferred over dialysis, as it allows for better physical and social rehabilitation, lowers the incidence of long-term complications such as cardiovascular disease and retinopathy, and improves overall survival.4,5 Living donor kidney transplantation is possible because the remaining kidney undergoes adaptive hypertrophy and hyperfiltration, thereby preserving sufficient renal function.Evaluation of GFR is central to donor and recipient assessment.In routine clinical practice, isotopic methods such as diethylenetriaminepentaacetic acid (DTPA) scanning are commonly employed, while creatininebased equations, including Cockcroft-Gault (CG) and the modification of diet in renal disease (MDRD) formula, are also widely used.6,7
Source: Journal of Medical Academics
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7116782205