Work

Synthesis of Unsymmetrical Dialkyl Ethers via Direct Etherification Cocatalyzed Using FeCl 3 ·6H 2 O and 1,1,1,3,3,3-Hexafluoroisopropanol

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Herein, a mild and efficient method for synthesizing unsymmetrical dialkyl ethers via direct etherification promoted by FeCl 3 ·6H 2 O and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is described. Carbocations produced from alcohols, cocatalyzed using FeCl 3 ·6H 2 O and HFIP, resulted in unsymmetrical dialkyl ethers through a unimolecular nucleophilic substitution mechanism. Unsymmetrical dialkyl thioethers could also be efficiently prepared using a similar approach.

Source: ACS Omega

DOI: 10.1021/acsomega.5c10269

Authors: Zhu-Cai Yang, Pu Zhang, Zhi-Xin Guo

Institution: Renmin University of China

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funder: Renmin University of China