Work

Microbiotoxicity: an under-recognised player in drug efficacy, toxicity, and health outcomes

Year: 2025

Type: article

Abstract: The gut microbiome regulates immunity, inflammation, and metabolism. Disruption by antibiotic and non-antibiotic drugs, termed microbiotoxicity, may impair efficacy of treatments, including cancer immunotherapy and vaccination, and contribute to antimicrobial resistance (AMR). This review explores microbiotoxicity's clinical impacts, highlighting non-antibiotic drug effects. Further research into drug-microbiome interactions in future may help inform prescribing practices and drug development as a way to improve health outcomes, reduce toxicity, and support AMR stewardship.

Source: npj Antimicrobials and Resistance

DOI: 10.1038/s44259-025-00165-5

Authors: Shirley Do Nascimento, Anastasia A. Theodosiou, Chrysi Sergaki

Institutions: Medicines and Healthcare products Regulatory Agency, University of Glasgow

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190