Obesity enhances salt-sensitivity of blood pressure, independent of skin electrolytes, and more in female than in male ZSF1 rats
Year: 2025
Type: article
Abstract: In the presence of obesity, salt-sensitivity of blood pressure was greater in female than in male ZSF1 rats, whereas in the absence of obesity, female rats were salt-resistant. Interestingly, these differences occurred without changes in sodium or potassium accumulation in the skin. These findings highlight that obesity leads to loss of female advantage in salt-sensitive hypertension and call into question the role of nonosmotic sodium storage in salt-sensitivity of blood pressure.
Language: English
Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Awards: G1399009114, G2349250568
OpenAlex ID: W7116880703