Work

Stereodivergent access to α- and β-azanucleosides via catalyst-free, achiral modulator-controlled iodocyclization: a concise synthesis of forodesine

Year: 2025

Type: article

Abstract: selectivity-the shortest route and highest stereoselectivity reported to date. DFT studies reveal that hydrogen bonding/Na-O coordination and π-π stacking interactions govern the stereochemical outcomes. This work provides an efficient, scalable platform for accessing diverse azanucleoside therapeutics.

Source: Chemical Science

DOI: 10.1039/d5sc08431h