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Susceptibility to Penicillin G and Ceftriaxone in 3 Clinical Treponema pallidum Isolates Is Not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein

Year: 2025

Type: article

Abstract: ABSTRACT We demonstrated no differences in susceptibility to penicillin G and ceftriaxone in three modern T. pallidum isolates (UW244B, UW249B, and UW330B), each carrying a variant of the penicillin-binding protein (PBP) Tp0705. This suggests that these polymorphisms should not be a reason for concern when β-lactams are prescribed for syphilis treatment. SUMMARY We report that three modern Treponem a pallidum isolates carrying amino acid polymorphisms at positions 506, 625, and 708 of the penicillin-binding protein (PBP) Tp0705 are equally susceptible to penicillin G and ceftriaxone.

Source: Sexually Transmitted Diseases

DOI: 10.1097/olq.0000000000002291

Authors: Lauren C. Tantalo, Kathyani D. Chamakuri, Alexander L. Greninger, Nicole A.P. Lieberman, Lorenzo Giacani

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institutes of Health