Work

Routine flumazenil administration confounds emergence time comparisons between remimazolam and propofol: a methodological concern

Year: 2025

Type: article

Abstract: This letter to the editor identifies a critical methodological concern in a recent clinical trial by Qin et al. that compared the emergence profiles of remimazolam and propofol in pediatric anesthesia. We argue that the study's findings are confounded by a fundamental"asymmetry in interventions". The remimazolam group routinely received flumazenil for pharmacological reversal, while the propofol group emerged spontaneously via natural metabolism.

Source: BMC Anesthesiology

DOI: 10.1186/s12871-025-03552-7

Authors: Haishan Cui, Qingjun Zeng, Yi Zhang

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190

OpenAlex ID: W7117101704