Work

Association of the triglyceride-glucose index and its derived indices with carotid artery plaques in postmenopausal women: a cross-sectional study

Year: 2025

Type: article

Abstract: OBJECTIVE: This study aimed to compare the associations of the triglyceride-glucose (TyG) index and its obesity-combined derivatives (TyG-BMI, TyG-WC, TyG-WHtR) with carotid artery plaques in a cohort of postmenopausal women. RESULTS: Among 435 postmenopausal women studied, the prevalence of carotid plaques was 36.6% (n = 159). Compared to the non-plaque group, women with plaques were older and had higher triglyceride levels and TyG index (all P < 0.01). In multivariable logistic regression analysis, after full adjustment for confounders including age, LDL-C, and cardiometabolic histories, only the TyG index maintained an independent association with plaque presence (OR = 1.471, 95% CI 1.044–2.073, P = 0.027). In contrast, none of the derivatives (TyG-BMI, TyG-WC, TyG-WHtR) showed significant associations. The TyG index demonstrated a modest predictive value for plaques (AUC = 0.593, P = 0.001), which was superior to its derivatives.

Source: BMC Research Notes

DOI: 10.1186/s13104-025-07597-2

Authors: Xiaoqin Chen, Xueru Ding, Min Liang, Li Li, Xia Dong, Xiang Zhao

Institution: First Affiliated Hospital of Xinjiang Medical University

Language: English

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690