Work

Pomegranate-induced refractory anaphylaxis in a toddler

Year: 2025

Type: article

Abstract: Pomegranate (Punica granatum) is a fruit rich in antioxidants and commonly consumed worldwide. However, although generally well tolerated, it has rarely been implicated in severe allergic reactions, including anaphylaxis. We report the case of a 3.5-year-old boy with a five-month history of recurrent periorbital angioedema. Careful history revealed pomegranate ingestion preceding one of these episodes. During an oral food challenge with pomegranate, he developed refractory anaphylaxis requiring repeated intramuscular administrations of epinephrine and a continuous epinephrine infusion. This case highlights that, despite being an uncommon food allergen, pomegranate can provoke life- threatening systemic reactions in children. Clinicians should be aware of this potential and consider it in the differential diagnosis of unexplained recurrent angioedema or anaphylaxis.

Source: Revue française d'allergologie

DOI: 10.1016/j.reval.2025.104640

Authors: E. Bahadir, B. Can Duran, S. Demirsöz, C. Aytekin, S. Özmen

Institution: Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi

Language: English

Topic: Food Allergy and Anaphylaxis Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,880