Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Relationships between bradycardia and cognitive trajectories and the underlying mechanisms remain unclear. The present study investigated associations bradycardia with longitudinal cognitive decline, circulating biomarkers, and cerebrovascular disease among subjects without atrial fibrillation (AF). METHOD: Resting heart rate (RHR) was recorded in memory clinic subjects with comprehensive neuropsychological assessment, brain magnetic resonance imaging, and blood samples. Longitudinal associations between bradycardia (RHR <60 bpm), compared to 60-69bpm, and cognitive decline (up to 5 years), graded at baseline and annually with the Clinical Dementia Rating (CDR)-sum of boxes score (CDR-SB) were ascertained. Cross-sectional associations between RHR and neuroimaging markers and circulating biomarkers were analysed. RESULT: *time=0.013) in linear mixed effects regression. Cross-sectionally, bradycardia was associated with higher levels of plasma neurofilament light chain (p = 0.033) and phosphorylated tau-181 (p = 0.003) levels, lower gray matter volume (p = 0.016), and higher counts of cortical infarcts (p = 0.049) compared to RHR 60-60bpm. CONCLUSION: Bradycardia was associated with accelerated cognitive decline. Further study into the mechanisms underpinning this association is required.
Source: Alzheimer s & Dementia
Authors: Lucia Li, Ming Ann Sim, Eugene Tan, Christopher Chen
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W7117111193
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