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Antituberculosis activity of α-aminoacyl amide derivatives

Year: 2025

Type: article

Abstract: The preparation and evaluation of α-aminoacyl amides derivatives against M. tuberculosis H37Rv is reported. The systematic modifications of hit compound were carried out. Compounds 19b and 19c are identified as potent and selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 µM and 2.6 µM respectively. Compounds 19b and 19c hold a promise for further development to discover new potent antituberculosis lead.

Source: Indian Journal of Chemistry

DOI: 10.56042/ijc.v64i12.19411

Authors: Haridas Rode, Vitthal Makane, Akash Sinde, Angayarkanni Balasubramaniyan, Pradip Malik, Sidharth Chopra, Vijayan Dusthackeer

Institutions: Indian Institute of Chemical Technology, Council of Scientific and Industrial Research, Academy of Scientific and Innovative Research, Central Drug Research Institute

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7117114259

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