Work

IFN-γ and IL-4 correlate with protection induced by an attenuated malaria vaccine

Year: 2025

Type: article

Abstract: Controlled human malaria infections after immunization via mosquito bites with radiation attenuated Plasmodium falciparum sporozoites are necessary tools to decipher immune signatures of malaria protection. The phenotype of circulating mononuclear innate cells and the PBMC response to in vitro stimulation unraveled correlates of protection from baseline immune response to sporozoite stimulation (IFN-ƴ secretion and HLA-DR high expression) to vaccine-induced immune factors (IL-4 secretion and CD57 - γδ T cell frequency).

Source: npj Vaccines

DOI: 10.1038/s41541-025-01308-5

Authors: Tanisha M. Robinson, Jessica S. Bolton, Elisabeth H. Duncan, Elke S. Bergmann-Leitner, Marie Mura

Institutions: Walter Reed Army Institute of Research, Service de Santé des Armées

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890