Work

Dietary phenolic compounds as modulators of AGEs-induced photo-oxidation: A focus on the skin and eye lens

Year: 2025

Type: article

Abstract: Advanced glycation end products (AGEs) are irreversible products formed when long-lived proteins undergo non-enzymatic reactions with reducing sugars or reactive metabolites. These products resist proteolytic degradation and therefore accumulate with age. Some AGEs act as chromophores, absorbing UVA-visible light and initiating photosensitized oxidation, a process implicated in photoaging of tissues such as the eye lens and skin. Dietary polyphenols, known for their antioxidant and antiglycation effects, may also modulate AGE-mediated photosensitized reactions, although this remains poorly understood. This article discusses the mechanisms through which AGEs contribute to photo-oxidative damage in light-exposed tissues and discusses the potential of dietary polyphenols to modulate these photo-induced processes.

Source: Redox Biochemistry and Chemistry

DOI: 10.1016/j.rbc.2025.100068

Authors: Felipe Ávila, Denis Fuentealba, Francisca Muñoz, Alejandra San Martin, Bertrand Friguet