Work

Composite Primary Outcomes in Nephrology Clinical Trials

Year: 2025

Type: article

Abstract: Composite study endpoints have made it possible to reduce the sample size and lower the cost of certain clinical trials. In nephrology trials, the use of composite endpoints has led to opportunities but has also created challenges in the interpretation of study results. In this perspective, we review how composite outcomes work and why there are risks attendant to their use. We also provide examples of the use of composite outcomes from specific nephrology trials and certain problems that resulted.

Source: Kidney Medicine

DOI: 10.1016/j.xkme.2025.101231

Authors: Steven Fishbane, Pratap Upadrista, Hitesh H. Shah

Institution: Northwell Health

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590