Global multi‐omics analysis of brain‐targeting exerkines in progressive treadmill‐exercised rodents
Year: 2025
Type: article
Abstract: BACKGROUND: Exercise offers neuroprotective and cognitive benefits against neurodegeneration in Alzheimer's disease, hypothesized to be due to the secretion of signaling molecules known as brain-targeting exerkines. However, the responsiveness of these exerkines across multiple organs remains poorly understood. METHOD: We leveraged the publicly available (MoTrPAC) dataset. Rats aged 6 months underwent a progressive treadmill training protocol. Blood (cells and plasma) and 18 solid tissues such as brain (cortex, hippocampus, hypothalamus) were collected, and multi-omics analyses were performed on them. We examined the protein and transcriptional expression of several brain-targeting exerkines across all collected tissues. RESULT: Brain-targeting, tissue-specific exerkine responsiveness ranked as follows: prosaposin > cathepsin B > Clusterin = FNDC5/irisin > platelet factor 4 > brain-derived neurotrophic factor (BDNF) = Gpld1. However, both the protein and transcriptional expression of all these brain-targeting exerkines remained unchanged in the brain across males and females throughout all 8 weeks of treadmill training. CONCLUSION: Contrary to previous studies, our analysis shows that brain-targeting exerkines remained unchanged in the brain after exercise, challenging the notion of a body-brain exerkine axis and questioning its role in neuroprotection and cognitive benefits.
Source: Alzheimer s & Dementia
Author: Hash Brown Taha
Institution: University of Southern California
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W7117124977
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