Work

Noncoding RNAs as Targets of Acute Kidney Injury Therapy

Year: 2025

Type: article

Abstract: AKI is a common clinical syndrome characterized by its complex pathophysiology and lack of effective therapeutic options, resulting in significantly increased mortality rates and a higher risk of progression to CKD. In recent years, noncoding RNAs (ncRNAs) have emerged as crucial regulators of gene expression and have been implicated in the onset and progression of AKI, particularly microRNAs, long noncoding RNAs, and circular RNAs. A growing body of research indicates that ncRNAs are not only involved in pathologic processes such as inflammation, apoptosis, and oxidative stress but also serve as promising early diagnostic biomarkers and potential therapeutic targets. This review systematically explores the molecular mechanisms of ncRNAs in AKI, their potential as therapeutic tools, and highlights recent advancements in the field along with the challenges of clinical translation. Ultimately, we assess whether ncRNA-targeted therapies are ready for clinical application in the management of AKI.

Source: Kidney360

DOI: 10.34067/kid.0000001118

Authors: Zhiwen Liu, Ying Fu, Juan Cai, Guochun Chen, Zheng Dong

Institutions: Central South University, Second Xiangya Hospital of Central South University, Augusta University, Charlie Norwood VA Medical Center

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Natural Science Foundation of Hunan Province