Work

A label-free fluorescent probe for deferiprone quantification in exhaled breath condensate utilizing UiO-66 MOF/ferric ions system

Year: 2025

Type: article

Abstract: This study developed a simple and label-free fluorescent probe for deferiprone quantification in exhaled breath condensate (EBC) samples. For that, UiO-66, synthesized in a one-step process with the solvothermal method, along with ferric ions, provided a selective system for deferiprone detection. Deferiprone formed a complex with ferric ions, and the resulting complex quenched the fluorescence intensity of UiO-66 through an inner filter effect process. The probe demonstrated good sensitivity, with a detection limit of 0.005 mg.L− 1 and a linear range of 0.016-1.0 mg.L− 1, and performed reliably in the analysis of deferiprone in EBC samples of the patients.

Source: Scientific Reports

DOI: 10.1038/s41598-025-33395-8

Authors: Nima Sheikh Abdollahzadeh Mamaghani, Zahra Karimzadeh, Maryam Khoubnasabjafari, Vahid Jouyban-Gharamaleki, Elaheh Rahimpour, Abolghasem Jouyban

Institutions: Tabriz University of Medical Sciences, Research Center for Pharmaceutical Nanotechnology

Language: English

Topic: Metal-Organic Frameworks: Synthesis and Applications

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690