Work

Recent advances in Pd-catalysed decarboxylative asymmetric allylic alkylation

Year: 2025

Type: article

Abstract: This comprehensive review on the Pd-catalysed decarboxylative asymmetric allylic alkylation details the development of this important transformation from its origins to more recent advances. Selected examples of this synthetically mild methodology being applied in natural product synthesis are given. The mechanism is explored in detail, to provide a thorough insight on the current understanding, which is built upon the combination of experimental and computational studies.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d5ob01686j

Authors: Niamh Lehane, Patrick J. Guiry

Institution: University College Dublin

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Science Foundation Ireland, Engineering and Physical Sciences Research Council, European Regional Development Fund

Awards: G1003336835, EPSRC-SFI Centre for Doctoral Training: Atoms-to-Products an Integrated Approach to Sustainable Chemistry, Bioeconomy Research Centre (BiOrbic)