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Synthesis of α-Glycerol Mono Caprylate from Protected Glycerol

Year: 2025

Type: article

Abstract: The synthesis of α-glycerol mono caprylate from protected glycerol has been carried out through a two-step reaction process. The transesterification reaction of methyl caprylate and protected glycerol (ratio 1:4) in the presence of 5% K2CO3 (w/w of the total reactant) as a catalyst and solvent-free produced a 1,2-acetonide-3-caprylil glycerol as a yellow viscous liquid with 61.8 % yield. The deprotection reaction of 1,2-acetonide-3-caprylil glycerol using Amberlyst-15 in ethanol for 20 hours at room temperature yielded crude α-glycerol monocaprilate. Purification of α-glycerol mono caprylate using hydro alcohol and n-hexane to produce a white solid with a yield and purity of 63.4% and 100%, respectively.

Source: Springer Link (Chiba Institute of Technology)

DOI: 10.1051/e3sconf/202568102002/pdf

Authors: Febri Odel Nitbani, Jefri Semuel Bale, Philiphi de Rozari, Sumaiya Bt Zainal Abidin, Putra Jiwamurwa Pama Tjitda, Anggelin Dete Nong Napa

Institutions: University of Nusa Cendana, Poltekkes Kemenkes Kupang

Language: English

Topic: Chemical Synthesis and Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7117147109

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