Work

β-Hydroxy-β-methylbutyrate enhances fast-twitch muscle and mitochondrial function, histopathology and mTORC1 signalling in the mdx dystrophic mouse

Year: 2025

Type: article

Abstract: This is the first study to examine the effect of HMB in 3-wk-old mdx mice undergoing extensive muscle damage and regeneration both in vivo and in vitro. HMB treatment increased voluntary grip strength and holding impulse, while elevating force production of isolated mdx EDL muscles, which were associated with improved muscle mass, muscle fiber size, and succinate dehydrogenase activity. Finally, these improvements coincided with increased markers of mTORC1 signalling, mitochondrial respiration, and ATP production.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00722.2025

Authors: Nicholas Giourmas, Hannah Lalunio, Chuhui Wu, Ryan Bagaric, Memphis Calzoni, Craig A. Goodman, Alan Hayes

Institutions: Western Health, Australian Institute for Musculoskeletal Science, Victoria University, The University of Melbourne

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7117149686

FWCI: 0.254

Cites: 72

Cited by: 1

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