A narrative review of vascular conduits for coronary artery bypass grafting
Year: 2025
Type: review
Abstract: Coronary artery bypass grafting (CABG) involves creating new conduits to restore blood flow to the heart. Using autologous vascular grafts presents challenges, including infection risk after vein harvesting, and scarcity of viable vein tissue. Researchers are exploring tissue-engineered vascular grafts (TEVGs), aiming to create optimal small-diameter vascular graft (SDVG) (<6 mm) for CABG surgery. TEVGs with suitable long-term patency could offer a promising alternative, potentially reduce patient morbidity and improve surgical outcomes. However, no SDVG is commercially available for CABG surgery in Europe, and no new clinical trials of coronary TEVGs have been reported since 2018. This narrative review summarizes the development and use of SDVG (<6 mm) for CABG, focusing on TEVGs and cell-seeding strategies. We outline the main types of grafts tested in preclinical and early clinical studies and highlight how different cell sources and seeding approaches aim to enhance graft functionality, patency, and long-term outcome.
Source: Cell Transplantation
Institutions: Universitat Autònoma de Barcelona, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Banc de Sang i Teixits, Institut de Recerca Sant Pau, Universitat Ramon Llull, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red, Hospital Universitario 12 De Octubre
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,650
Awards: G1118044486, G1685326032, G1762634998, Validación analítica y clínica del primer immunoensayo para personalizar estrategias terapéuticas en pacientes con shock cardiogénico, Modulación de la inflamación mediante Vesículas Extracelulares (VE) en el shock cardiogénico derivado de STEMI: EV4MI Trial., BASE GENÉTICA Y BIOLÓGICA DE LA CARDIOPATÍA INDUCIDA POR MARCAPASO, Evaluación multiparamétrica de la congestión en pacientes con insuficiencia cardiaca: precisión pronóstica de la congestión vascular por ecografía y correlación con biomarcadores cardiacos, Método in vitro para la predicción del riesgo de mortalidad en pacientes con shock cardiogénico
OpenAlex ID: W7117151848