Work

MHC-II polymorphism in tuberculosis control: general lessons from focused studies in mice

Year: 2025

Type: article

Abstract: CD4+ T-cells are critical for effective anti-mycobacterial immune response. The MHC-II genes encoding Class II molecules, key regulators of CD4+ T-cell selection in the thymus and maintenance in the periphery, are a prominent factor of tuberculosis (TB) control. Recent genetic mapping and functional studies performed in our lab provided new facts about the influence of MHC-II genetic polymorphisms on the expression level of Class II molecules on the surface of antigen-presenting cells (APCs) in organs of the immune system and in the lungs. We also determined how these variations affect TB control by the murine host. In this short Opinion article, we summarize and briefly discuss our conclusions from this work.

Source: Academia Immunity and Disease

DOI: 10.20935/acadimmunodis8068

Authors: Tatiana Kondratieva, Nadezhda Logunova, Alexander Apt

Institution: Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7117162035

FWCI:

Cites: 34

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