Year: 2025
Type: article
Abstract: Background Integrating biological and clinical staging could reveal factors underlying Alzheimer's disease (AD) heterogeneity. Method In 193 participants from the Alzheimer's Disease Neuroimaging Initiative, the discrepancy between clinical stage (cognition) and biological stage (tau deposition) was measured using standardized residuals (W‐score) to classify groups: concordant stage (W 0 ), worse clinical stage (W ‐ ), and better clinical stage (W + ). Result The W ‐ group showed faster cognitive decline and higher progression risk (HR = 2.40, 95% CI = 1.20 – 4.83), while the W + group had lower progression risk (HR = 0.43, 95% CI = 0.19 – 0.96). Co‐pathology burden was correlated with W‐scores, and the W ‐ group had higher ratio of cerebrospinal α‐synuclein positivity. Lower brain metabolism was observed in the W ‐ group, whereas higher brain metabolism was noted in the W + group compared to the W 0 group. Conclusion Integrated staging scheme has clinical implications on predicting AD prognosis and underlying co‐pathology.
Source: Alzheimer s & Dementia
Author: Young‐gun Lee
Institution: Inje University Ilsan Paik Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W7117247404
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