Patent Ductus Arteriosus in Preterm Neonates: A 2025 Synthesis of Evidence‐Based Paradigms and Emerging Clinical Strategies
Year: 2025
Type: article
Abstract: The American Academy of Pediatrics (AAP) recently published an updated clinical report on the management of patent ductus arteriosus (PDA) in preterm infants authored by Ambalavanan, Aucott, Salavitabar, Levy, and the Committee on Fetus and Newborn and Section on Cardiology and Cardiac Surgery [1].This comprehensive report addresses the ongoing controversies and uncertainties surrounding PDA management, providing evidence-based guidance for clinicians caring for preterm infants (Table 1). | Understanding PDA in Preterm InfantsThe ductus arteriosus is a fetal blood vessel that typically closes shortly after birth in term infants.However, in preterm infants, especially those born at extreme prematurity, this closure is often delayed.The report highlights that spontaneous closure rates vary significantly by gestational age: whereas the ductus remains open at 4 days in only 10% of infants born at 30-37 weeks, it persists in more than 90% of those born at 24 weeks gestation [1].This clinical challenge is particularly complex when a PDA becomes "hemodynamically significant" (hsPDA) and requires intervention.The persistence of a PDA can lead to increased pulmonary blood flow and potential "ductal stealing" from systemic circulation, which may contribute to complications, including bronchopulmonary dysplasia, necrotizing enterocolitis, and intraventricular hemorrhage [1].However, the report emphasized that these associations do not necessarily prove causation, which partly explains the ongoing debate about optimal management strategies.
Source: Pediatric Discovery
DOI: 10.1002/pdi3.70032
Institution: Bhaikaka University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7117255018