Work

C7-Sulfonamide functionalization of 7-deazaadenosines: sangivamycin analogues with Haspin inhibitory activity

Year: 2025

Type: article

Abstract: We report a robust method for C7-sulfonamide installation on 7-deazaadenosines, enabled by an unprecedentedly stable sulfonyl chloride. This general transformation introduces a new functionalization site and expands nucleoside chemical space, offering a powerful platform for constructing tailored probes and analogues in synthetic and bioorganic chemistry.

Source: Chemical Communications

DOI: 10.1039/d5cc06746d

Authors: Milan Štefek, Milan Dejmek, Michal Šála, Radim Nencka

Institutions: Czech Academy of Sciences, Charles University, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: European Commission, Ministerstvo Školství, Mládeže a Tělovýchovy, Akademie Věd České Republiky, Ústav organické chemie a biochemie Akademie věd České republiky