RNF186 as a prognostic biomarker and its correlation with immune cell infiltration in clear cell renal cell carcinoma
Year: 2025
Type: article
Abstract: BACKGROUND: Ring finger 186 (RNF186) is implicated in cancer development, but its role in clear cell renal cell carcinoma (ccRCC) remains unclear. METHODS: RNF186 expression was analyzed using TCGA, GEO, and clinical samples. Its diagnostic and prognostic significance, protein interactions, functional pathways, immune microenvironment associations, and drug sensitivity were evaluated. Single-cell analysis and molecular docking were also performed. RESULTS: RNF186 was significantly upregulated in ccRCC and negatively correlated with advanced tumor stage. High RNF186 expression indicated better prognosis and showed diagnostic value. It participated in key biological processes and immune modulation, with predominant enrichment in malignant cells. Elevated RNF186 expression was linked to enhanced sensitivity to targeted therapies like sunitinib, which exhibited a favorable predicted binding energy. CONCLUSION: RNF186 serves as a potential biomarker for prognosis prediction, tumor microenvironment characterization, and personalized targeted therapy in ccRCC.
Source: Biomarkers
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7117299882