Work

De novo arthropathy following glucocorticoid treatment for severe alcohol-associated hepatitis: Five case reports

Year: 2025

Type: article

Abstract: BACKGROUND Glucocorticoids (GC) are the cornerstone in the treatment of severe alcohol-associated hepatitis (SAH) but may be associated with adverse events. CASE SUMMARY We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation. Five patients were included in this series, three of whom were women. All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics. Final diagnoses were: Arthralgia associated with GC cessation (n = 3), polymyalgia rheumatica (n = 1) and psoriatic arthritis (n = 1). Joint soreness was the main symptom, whereas arthritis occurred rarely. Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term. CONCLUSION De novo arthropathy may occur following GC for SAH. Close monitoring and tapering regimes are advised.

Source: World Journal of Hepatology

DOI: 10.4254/wjh.v17.i12.110931

Authors: Queralt Herms, Sonia Torres, Patrick S Kamath, Jordi Gratacós-Ginès, Elisa Pose

Institutions: Hospital Clínic de Barcelona, Mayo Clinic, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona

Language: English

Topic: Alcohol Consumption and Health Effects

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7117301180