Figure 1 from Periostin Promotes Sarcoma Growth by Promoting Tumor-Associated Macrophage Migration and Differentiation
Year: 2025
Type: other
Abstract: POSTN expression is correlated with patient survival and expression of extracellular matrix proteins. A, Kaplan–Meier plot showing reduced survival for patients with sarcoma expressing high POSTN levels. B and C, Pathway analysis of patients with sarcoma showing high vs. low POSTN expression levels revealed increased expression of ECM-related elements in POSTN-high patients. D, Schematic representation of the sarcoma mouse models. E, Volcano plot of select differentially expressed genes in tumor cells sorted from the p53KOVgll3OE (positive log fold change) vs. p53KOCcne1OE (negative log fold change) mouse tumors. F, Heat map showing the most differentially expressed soluble factors in the ELISA array comparing p53KOVgll3OE vs. p53KOCcne1OE whole tumors. G, Expression of Postn mRNA in tumor cells, adjacent CAFs, and bone marrow–derived mesenchymal cells (CD45− PDGFRA+). Unless otherwise indicated, results are presented as mean ± SEM, and P values were derived from a two-tailed unpaired Student t test (*, P < 0.05). [Created in BioRender. Guarnerio, J. (2025) https://BioRender.com/fo00cpj.]
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7117302655