Work

Increased Expression of Angiopoietin 2 and Tie2 in Rosacea

Year: 2025

Type: article

Abstract: In this study we evaluated the expression of Angiopoietin 1, Angiopoietin 2, and Tie2 by immunohistochemistry in the skin of 10 patients with erythemato telangiectatic and papulopustular rosacea. Significantly increased expression of Tie2 and Angiopoietin 2 in the endothelial cells of the dermal vessels in rosacea skin vs. non-lesional skin (100% and 33.3% for Tie2, and 100% and 50% for Angiopoietin 2) was observed. There was no difference in the expression of Angiopoietin 1 and phosphorylated Tie2 (pTie2) between the lesional skin of rosacea and non-lesional skin.

Source: Dermatopathology

DOI: 10.3390/dermatopathology13010002

Authors: Aysin Kaya, Jean-Hilaire Saurat, Nathalie Satta, Gürkan Kaya

Institutions: University of Geneva, University Hospital of Geneva

Language: English

Topic: Acne and Rosacea Treatments and Effects

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,810