424P Targeting the lipid metabolism–mitophagy axis in TAMs to enhance immunotherapy
Year: 2025
Type: article
Abstract: Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME) and are critical mediators of immune suppression. Enhanced lipid metabolism is a hallmark of TAMs, yet how lipid accumulation drives their pro-tumorigenic function remains poorly defined. Mitophagy, a selective form of autophagy that removes damaged mitochondria, has recently emerged as a regulator of immune cell fate. However, whether tumor-derived lipids exploit mitophagy to sustain TAM-mediated immune suppression is unknown.
Source: Immuno-Oncology Technology
Author: P-S. Liu
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,340
OpenAlex ID: W7117307628
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