Work

417P Nucleotide sanitation as treg survival and proliferation mechanism in hypoxic conditions

Year: 2025

Type: article

Abstract: Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, therapeutic responses are highly variable, in part due to immunosuppressive resistance mechanisms driven by specific cell populations, including CD4+ regulatory T cells (Treg). Our study has revealed the overexpression of the nucleotide sanitizer enzyme DNPH1 in Treg cells in ICB non-responder patients. DNPH1 hydrolyzes modified nucleotide hydroxymethyldeoxyuridine (hmdU) monophosphate, preventing its integration into the DNA.

Source: Immuno-Oncology Technology

DOI: 10.1016/j.iotech.2025.101414

Authors: C. Copes, J. Swatler, I. Rotella, M. De Luca, E. Mazza, E. Lugli

Institution: IRCCS Humanitas Research Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,340