Work

Selective modulation of murine intestinal M 1 and M 3 muscarinic receptor expression has divergent effects on specialized epithelial cells and body weight

Year: 2025

Type: article

Abstract: Small intestinal goblet cells robustly express both Chrm1 and Chrm3; mucosal immune cells express primarily Chrm3. Mice with intestinal epithelial cell (IEC) Chrm3/M 3 R deletion have fewer small intestinal goblet cells but more tuft cells. The increase in tuft cells, which produce acetylcholine, may represent a feedback mechanism to compensate for reduced muscarinic receptor (MR) expression. IEC-selective deletion of MRs does not impact murine weight or enteroid development, suggesting that MRs beyond the intestinal epithelium regulate weight.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00739.2025

Authors: Natalia Sampaio Moura, Alyssa Schledwitz, Kunrong Cheng, Yang Song, Min Seong Kwon, Cassandra A. Cairns, Lea-Pearl Njei, Benjamin Raufman, Cinthia B. Drachenberg, Jian-Ying Wang, Bing Ma, Jean-Pierre Raufman

Institutions: University of Maryland, Baltimore, University of Maryland School of Medicine, VA Maryland Health Care System

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Veterans Affairs, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Research Training in Gastroenterology and Hepatology, Mucosal Repair in Gut Surgical Disorders, G419207888, G5712744286, Surgical Studies of Gut Permeability, G9000162260, UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANT, CTSA Postdoctoral T32 at Johns Hopkins, Intestinal Mucosal Growth in Health and Surgical Diseases

OpenAlex ID: W7117313302

FWCI: 0.839

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Cited by: 1

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