Work

Naringenin attenuates inflammation and apoptosis in lipopolysaccharide-induced H9c2 cardiomyocytes

Year: 2025

Type: article

Abstract: Naringenin, a natural flavonoid, has various pharmacological effects. However, the function of naringenin in cardiac inflammation remains unclear. This study investigated whether naringenin alleviates cardiac inflammatory induced by lipopolysaccharide (LPS). Naringenin's regulatory targets in inflammation and apoptosis were investigated using network pharmacology and molecular docking. LPS activated H9c2 cardiomyocytes, which were then treated with naringenin. Naringenin (20 or 40 μM) reduced the expression of cytokine induced by LPS (P < 0.05). In LPS-induced cells treated with naringenin (20 μM), the nuclear translocation of p65 was inhibited, concomitantly with a significant reduction in IκBα degradation. TUNEL staining revealed that naringenin (20 μM) significantly reduced apoptosis triggered by LPS (P < 0.05). Naringenin (20 μM) also significantly decreased the expression level of Bax and cleaved-caspase 3, and significantly elevated Bcl-2 expression. Naringenin may be able to attenuate H9c2 cardiomyocyte inflammation and apoptosis induced by LPS.

Source: Journal of Radiation Research and Applied Sciences

DOI: 10.1016/j.jrras.2025.102115

Authors: Fang Wang, Rui Dai

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,400

Funder: National Natural Science Foundation of China