Work

353P FGF2-high CAFs regulate immunosuppression in non-small cell lung cancer via NUPR1 in tumor-associated macrophages

Year: 2025

Type: article

Abstract: Non-small cell lung cancer (NSCLC) remains a major cause of cancer mortality worldwide. Despite advances in immunotherapy, treatment resistance persists due to unclear mechanisms.Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment with diverse functions in matrix remodeling, angiogenesis, and immune regulation. CAF heterogeneity enables both pro- and anti-tumor roles, with recent single-cell studies revealing new subtypes across cancers.Fibroblast growth factor 2 (FGF2) is a multifunctional cytokine involved in immune modulation and TME remodeling.

Source: Immuno-Oncology Technology

DOI: 10.1016/j.iotech.2025.101350

Authors: W. Shi, J. Wang, Z. Meng, Z. Li

Institutions: Shanghai Jiao Tong University, Shanghai Chest Hospital

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,340