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304eP Integrative transcriptomic profiling of tumor antigens and immune genes in pancreatic cancer for rational ADCDesign

Year: 2025

Type: article

Abstract: Pancreatic adenocarcinoma (PAAD) is an aggressive malignancy with poor overall survival. Identifying tumor-associated antigens (TAAs) is essential for developing antibody-drug conjugates (ADCs) and bispecific therapies. Their combination with immune checkpoint inhibitors (ICIs) may improve clinical outcomes. We conducted transcriptomic co-expression analysis of TAAs and immune-related genes (IEGs) in PAAD, including both suppressive and activating markers.

Source: Immuno-Oncology Technology

DOI: 10.1016/j.iotech.2025.101503

Authors: A. Cabello Izquierdo, M. Amann Arevalo, B. García Paredes, M. Granja Ortega, I. Moreno, A.G. Escudero, M. García Gómez, B.G. Diez, S. Repáraz Herrero, M. Vizcaino Escoto, A. Ocaña, P. Pérez Segura, J. Sastre Valera, J. Bartolomé Arcilla

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,340

OpenAlex ID: W7117322964

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