Work

Bilateral breast plasmacytomas in a male patient with relapsed multiple myeloma: A case report

Year: 2025

Type: article

Abstract: Breast involvement in multiple myeloma (MM) is rare, and bilateral plasmacytomas in male patients are exceptionally uncommon. We report a 73-year-old man with relapsed IgG kappa MM who presented with new-onset gynecomastia and multiple palpable masses in both breasts and axillae. Contrast-enhanced mammography demonstrated multiple enhancing bilateral breast masses, with heterogeneous enhancement on recombined images and corresponding hypoechoic masses on ultrasound. Core biopsy confirmed plasma cell neoplasm (CD138+, CD56+, kappa-restricted). CT revealed disseminated extramedullary disease involving the liver, retroperitoneum, pancreas, and bones. Despite supportive care, the patient deteriorated rapidly and died 1 month later. This case highlights the diagnostic value of contrast-enhanced mammography in detecting multifocal breast plasmacytomas and underscores the clinical significance of bilateral extramedullary relapse in male MM.

Source: Radiology Case Reports

DOI: 10.1016/j.radcr.2025.11.054

Authors: Ilze Eņģele, Tatjana Zablocka, Evija Asere, Jānis Eglītis

Institutions: Riga East University Hospital, University of Latvia

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600