Work

386P WITHDRAWN: Acrolein drives p38 MAPK activation in neutrophils via thioredoxin alkylation and promotes immunosuppression in the glioma microenvironment

Year: 2025

Type: article

Abstract: Acrolein (Acr), a highly reactive aldehyde generated under hypoxic tumor microenvironment, disrupting redox homeostasis through the covalently modification of thioredoxin (Trx), one of the major cellular antioxidant pathways. Neutrophils, the most abundant immune cells in the blood, have been reported to exhibit immunosuppressive properties in cancers. However, the underlying mechanisms of neutrophil reprogramming in TME remain unclear. Glioblastoma (GBM) is a malignant brain tumor in the world, and has a poor prognosis correlated with the number of infiltrated neutrophils in glioma TME.

Source: Immuno-Oncology Technology

DOI: 10.1016/j.iotech.2025.101383

Author: T.J. Zhen Jie

Institution: National Yang Ming Chiao Tung University

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,340