Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs
Year: 2025
Type: article
Abstract: BACKGROUND: Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. METHODS: The medical records of a single institution were reviewed for dogs that received IV AMC. Data recorded included clinical signs suggestive of an immediate allergic adverse reaction. RESULTS: A total of 431 dogs received IV AMC and 20 were suspected to have had an immediate allergic adverse reaction. Six out of the 20 dogs were excluded due to concurrent drug administration. In 11 dogs, signs were classified as grade 1 with facial oedema and facial pruritus being the most common clinical features of an immediate allergic adverse reaction. The percentage frequency of AMC-associated immediate adverse reactions was 3.3%. LIMITATIONS: The study's retrospective design, small sample size, inclusion of a solely referral population, use of an unvalidated grading tool and classification of reactions by a single author may limit generalisability. CONCLUSION: Immediate allergic adverse reactions to IV AMC in conscious dogs are clinically mild and primarily cutaneous.
Source: Veterinary Record
DOI: 10.1002/vetr.70172
Authors: Leonel Frutuoso, Anna Threlfall
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,980
OpenAlex ID: W7117328896