Work

Anti-inflammatory and antioxidant mechanisms of Morus species: Part-specific insights from traditional Chinese medicine

Year: 2025

Type: article

Abstract: Introduction Various parts of the Morus species have long been used in TCM, which are increasingly known for their anti-oxidant and anti-inflammatory properties. This review systematically explores the phytochemical composition and therapeutic relevance of Morus species within the TCM framework. Methods A comprehensive literature analysis was conducted across ScienceDirect.PubMed and Google Scholar, concentrating more on peer-reviewed English-language articles, clinical trials, and reviews published up to 2025. Results Out of the initial 297 sources identified, 165 were selected for relevance to Morus and its bioactive constituents. More emphasis has been placed on those studies providing part-specific information on leaves, bark, stems, fruits, twigs, and roots, which are commonly used in traditional formulations. The review maps the distribution of phytochemicals across these botanical parts and highlights their pharmacological actions with special attention to anti-inflammatory and antioxidant mechanisms. Key compounds discussed in relation to modulation of oxidative stress, inflammatory pathways, and possible clinical applications include flavonoids, alkaloids, and polyphenols. Discussion The current synthesis provides a comprehensive phytochemical profile of Morus species and emphasizes their therapeutic potential in the management of chronic inflammatory-degenerative disorders. Despite this promise, the effects await further confirmation by targeted pharmacological studies and well-designed clinical trials. Elucidation of the role of bioactive compounds from Morus species might help to include such compounds in evidence-based complementary medicine and drug development strategies.

Source: Pharmacological Research - Modern Chinese Medicine

DOI: 10.1016/j.prmcm.2025.100749

Authors: Akash Bhati, Hemanth Kumar Boyina, Navneet Sharma

Institution: Chandigarh University

Language: English

Topic: Phytochemistry and Biological Activities

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,550