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Sertraline-Induced Lipase-Sparing Acute Interstitial Edematous Pancreatitis: A Case Report

Year: 2025

Type: article

Abstract: Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been associated with rare cases of acute pancreatitis. We report a case of sertraline-induced, lipase-sparing acute interstitial edematous pancreatitis in a young professional, initially misdiagnosed as acute cholecystitis. On rechallenge, the patient developed recurrent symptoms with elevated inflammatory markers but normal ultrasound findings. Contrast-enhanced computed tomography confirmed acute interstitial edematous pancreatitis with associated venous thrombosis. Withdrawal of sertraline and substitution with an alternative antidepressant led to complete resolution. This case highlights the diagnostic challenge of lipase-sparing pancreatitis and underscores the importance of considering drug-induced etiologies.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18058156

Authors: Zaparackaite I, Singh H, Singh SJ, Swamy KB, Midha PK, Patel RV

Institutions: Evelina London Children's Healthcare, Nottingham University Hospitals NHS Trust, Lincoln University College

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7117361672

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