Work

Lack of unconventional myosin VI is associated with brain enlargement and gliosis progressing with age

Year: 2025

Type: article

Abstract: Myosin VI (MVI) is a unique unconventional myosin which, unlike other myosins, moves towards the minus end of actin filaments. It is involved in numerous cellular processes such as endocytosis and trafficking, cell migration and adhesion, and gene transcription. It is widely expressed in all tissues, including the brain. Its lack in adult murine brains is associated with gliosis and impairment of neuronal transmission. Here, we demonstrate that the MVI level in the total mouse brain and its regions (cerebral cortex, cerebellum, and hippocampus) increases with the animal's age (from newborn up to 12‑month‑old mice). Its lack leads to enlargement of the brain and its examined areas, and an increase of the level of GFAP, the marker of glia cells, in adult mice. The data indicate an involvement of MVI in the brain maturation and possibly in development of an age‑dependent gliosis.

Source: Acta Neurobiologiae Experimentalis

DOI: 10.55782/1zwmve34

Authors: Jolanta Nowak, Justyna Karolczak, Henryk Bilski, Serge Weis, Maria Jolanta Rędowicz

Institutions: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego, Polish Academy of Sciences, Johannes Kepler University of Linz, Kepler Universitätsklinikum

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Cambridge Institute for Medical Research, University of Cambridge