Work

Progress on experimental models of neuromyelitis optica spectrum disease

Year: 2025

Type: article

Abstract: Neuromyelitis optica spectrum disease (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects the optic nerve and spinal cord. At present, the etiology and pathogenesis of NMOSD have not been fully clarified, and its treatment is not perfect, and ideal animal models are a key tool to explore the disease mechanism and screen therapeutic drugs. In recent years, the discovery and confirmation of neuromyelitis optica immunoglobulin G (anti-AQP4 antibodies) as aquaporin-4 (AQP4)-specific antibodies have greatly promoted the study of the pathogenesis of NMOSD, and the study of animal models of NMOSD has become a hot topic of current attention. This article reviews the research progress of NMOSD animal models in recent years, providing a reference for further promoting the in-depth understanding of NMOSD and the formulation of treatment plans.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2025.12.013

Authors: Guo Yawen, Yao Shunyu, Jiang Daiyi, Lin Lanxin, Wu Siliang, Peng Yong

Institutions: Hunan University of Traditional Chinese Medicine, Hunan Traditional Chinese Medical College

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,400