Tumor Control After Radiosurgery in Sporadic and Neurofibromatosis Type 2 Vestibular Schwannomas
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The tumor control rate after stereotactic radiosurgery (SRS) for neurofibromatosis type 2-associated vestibular schwannomas (NF2-VSs) compared to sporadic vestibular schwannomas (S-VSs) remains unclear. This nationwide, multicenter, retrospective study (KGKRS-21-001) aimed to clarify this issue. METHODS: A total of 4718 patients treated with SRS for vestibular schwannomas were analyzed from 13 nationwide institutions in Korea. NF2-VS cases were propensity score-matched with S-VS cases at a ratio of 1:1, based on age, tumor volume, and marginal dose, resulting in 122 cases in each group. RESULTS: No significant differences in age, tumor volume, or marginal dose were observed between the matched cohorts. The overall tumor control rates at 1, 3, and 10 years after SRS were 93.3%, 87.7%, and 80.7%, respectively, with no significant difference between NF2-VS and S-VS groups (p = 0.63). Subgroup analysis showed that age ≤ 19 years was a significant negative prognostic factor for tumor control in NF2-VS patients (p < 0.001), whereas no such correlation was found in the S-VS cohort (p = 0.78). CONCLUSIONS: SRS provides comparable tumor control for NF2-VSs and S-VSs. However, among NF2-VS patients, younger age (≤ 19 years) was associated with poorer tumor control, suggesting that age may be a critical factor in treatment decisions.
Source: Cancer Medicine
DOI: 10.1002/cam4.71480
Authors: So Young Ji, Young‐Hoon Kim, Won Seok Chang, Ho Kang, Jung‐Il Lee, Jung Ho Han, Chae‐Yong Kim, Jong Hyun Kim, Hae Won Roh, Jeong‐Hyun Hwang, Seong‐Hyun Park, Young‐Cho Koh, Joon Cho, Seok Keun Choi, Chang Kyu Park, Se‐Hyuk Kim, Tae Hoon Roh, Sang Ryul Lee, Sang‐Won Lee, Soon‐Ki Sung, Moo Seong Kim, Won Hee Lee, Sun‐Il Lee, Seon‐Hwan Kim, Sae Hun Kim, Kyung Hwan Kim, Jung‐Won Choi, Ho Jun Seol, Young Hyun Cho, Junhyung Kim, Hyun Ho Jung, Jong Hee Chang
Institutions: Seoul National University Bundang Hospital, Asan Medical Center, University of Ulsan, Severance Hospital, Samsung Medical Center, Korea University Guro Hospital, Kyungpook National University Hospital, Kyungpook National University, Kyungpook National University Medical Center, Konkuk University Medical Center, Kyung Hee University Medical Center, Ajou University Hospital, Chungnam National University Hospital, Ajou University Medical Center, Inje University Haeundae Paik Hospital, Pusan National University Yangsan Hospital, Inje University Busan Paik Hospital
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,700
OpenAlex ID: W7117369548