Asthma remission and its predictors in severe asthma: real-world study from the Korean severe asthma registry
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Remission has emerged as a therapeutic goal in asthma, but most studies in severe asthma have focused on biologic-treated patients in controlled settings. Real-world data from Asian populations are scarce. We aimed to evaluate the achievement and predictors of asthma remission in Korean patients with severe asthma using a nationwide prospective cohort. METHODS: We analyzed 405 patients with severe asthma from the Korean Severe Asthma Registry (KoSAR) who completed 12-month follow-up. Remission was classified at 12 and 24 months as complete clinical remission (CCR; ACT ≥ 20, no exacerbations, no oral corticosteroid [OCS] use, and FEV₁ ≥80% or improvement ≥ 100 mL), clinical remission (CR; first three criteria), partial remission (PR; ≥1 criterion), and no remission (NR; none). Ordinal logistic regression identified baseline predictors of higher remission. RESULTS: At 12 months, CCR, CR, PR, and NR were achieved in 5.9%, 18.3%, 67.9%, and 7.9% of participants. Among those with 24-month follow-up (n = 139), remission status was largely stable. Higher baseline ACT score (OR: 1.19, 95% CI 1.12-1.27) predicted remission, while maintenance OCS use (OR: 0.11, 95% CI 0.05-0.25) and chronic cough (OR: 0.39, 95% CI 0.17-0.89) were negatively associated. Remission groups had better baseline lung function, fewer exacerbations, and low WBC counts. Baseline biologic use was more common in CCR, CR groups, whereas NR patients more frequently received methylxanthines, macrolides, and OCS. CONCLUSIONS: Clinical predictors, including asthma control, OCS use, and chronic cough may help guide remission-focused strategies in the treatment of severe asthma.
Source: Respiratory Research
Authors: Seung-Eun Lee, Byung-Keun Kim, Noeul Kang, Youngsoo Lee, Yoon-Seok Chang, Da Woon Sim, Hyo-In Rhyou, Jae-Woo Jung, Jae-Woo Kwon, Sujeong Kim, Taehoon Lee, Ga-Young Ban, Kyoung-Hee Sohn, Sang-Hoon Kim, An-Soo Jang, Sung-Yoon Kang, Min Suk Yang, So Ri Kim, Hyun Jung Jin, Young-Hee Nam, Ji Hyun Oh, Min-Hye Kim, Jin An, Hwa Young Lee, Han-Ki Park, Eun-Jung Jo, Ji-Ho Lee, Heung-Woo Park, Joo-Hee Kim, Woo-Jung Song, Sang-Heon Kim, So-Young Park
Institutions: Pusan National University Yangsan Hospital, Pusan National University, Korea University, Samsung Medical Center, Sungkyunkwan University, Ajou University, Seoul National University, Seoul National University Bundang Hospital, Chonnam National University, Chonnam National University Hospital, Inje University, Inje University Haeundae Paik Hospital, Chung-Ang University Hospital, Chung-Ang University Healthcare System, Chung-Ang University, Kangwon National University Hospital, Eulji University, Kyungpook National University, Jeonbuk National University Hospital, Hanyang University, Jeonbuk National University, Ulsan University Hospital, Hallym University, Kyung Hee University, Kyung Hee University Medical Center, Soonchunhyang University Hospital Bucheon, Gachon University Gil Medical Center, SNUH SMG-SNU Boramae Medical Center, Yeungnam University Medical Center, Yeungnam University College, Yeungnam University, Dong-A University, Kosin University, Ewha Womans University, Ewha Womans University Seoul Hospital, Kyung Hee University Hospital at Gangdong, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, Kyungpook National University Chilgok Hospital, Yonsei University, Wonju Severance Christian Hospital, Yonsei University Mirae Campus, Hallym University Sacred Heart Hospital, Asan Medical Center, University of Ulsan, Chung-Ang University Gwangmyeong Hospital
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Award: G2356689393
OpenAlex ID: W7117370868