Work

Immunomodulatory Fibrous Scaffold with Dual Enzyme‐Mimic Activities Prevents Postsurgical Tumor Recurrence

Year: 2025

Type: article

Abstract: ABSTRACT Surgical resection remains the frontline treatment for solid tumors. However, postsurgical recurrence driven by residual tumor cells and an immunosuppressive microenvironment continues to challenge long‐term survival. Here, we propose an implantable fibrous scaffold functionalized with MnO x nanozymes to prevent tumor recurrence. The dual enzyme‐mimic activities of the MnO x nanozymes endow the scaffold with immunomodulatory functions. On one hand, the MnO x nanozymes with peroxidase‐like activity catalyze the formation of cytotoxic hydroxyl radicals to trigger immunogenic cell death and antigen release. On the other hand, the catalase‐like activity helps alleviate hypoxia by decomposing H 2 O 2 to O 2 , thereby reprogramming macrophages toward a pro‐inflammatory M1 phenotype. Concurrently, the released Mn 2+ ions serve as a potent immune adjuvant, promoting immune cell recruitment and activation. The coordinated immunomodulatory cascade enables the scaffold to establish a sustained local immune niche. Both in vitro and in vivo evaluations confirm that this MnO x ‐functionalized scaffold elicits robust antitumor immunity, effectively preventing postsurgical recurrence without exogenous immunostimulants. This work highlights a material‐based immunotherapeutic strategy that leverages the intrinsic catalytic and immunomodulatory properties of nanozymes to engineer bioactive scaffolds for postoperative cancer treatment.

Source: Advanced Science

DOI: 10.1002/advs.202519431