Work

Sorafenib-associated Trichodysplasia Spinulosa versus Follicular Hyperkeratosis: a case report

Year: 2025

Type: article

Abstract: Sorafenib is a multi-target kinase inhibitor used to treat advanced cancers, such as hepatocellular carcinoma. It has been associated with various cutaneous adverse events and here we report a new potential skin reaction-Trichodysplasia Spinulosa (TS)-and explore its differential diagnosis with Follicular Hyperkeratosis (FH), both possibly induced by Sorafenib. we highlight the role of sorafenib in disrupting skin keratinization process and propose a mechanism for this reaction, especially in immunosuppressed individuals.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omaf273

Authors: Reem Hasan, Nemat Alsaghir, Kinda Alshawa, Sajeda Alnabelsi, Hanaa Almsokar

Institution: Damascus University

Language: English

Topic: Chemotherapy-related skin toxicity

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,103