Work

Large rectal Tubulovillous adenoma leading to McKittrick–Wheelock syndrome

Year: 2025

Type: article

Abstract: McKittrick-Wheelock syndrome (MWS) is a rare condition characterized by chronic diarrhea caused by colorectal villous adenoma, which can lead to severe hyponatremia, hypokalemia, and kidney injury. We present a case of MWS resulting from a 9.6 cm rectal tubulovillous adenoma, which caused significant electrolyte abnormalities and kidney injury. While MWS has been documented in association with villous adenomas, there is limited literature on its occurrence with tubulovillous adenomas, as seen in our case.

Source: Oxford Medical Case Reports

DOI: 10.1093/omcr/omaf267

Authors: Mohamad Bahrou, Muhammed Yaman Swied, Ayesha Ali, Elizabeth Tatum

Institution: SIU Medicine

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,103