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Chronic Inflammation as Homeostatic Lock-In A Systems Framework for Autoimmune Disease

Year: 2025

Type: article

Abstract: Chronic inflammatory and autoimmune diseases often persist despite effective suppression of immune activity, challenging models that equate symptom control with recovery. This paper proposes a systems-level framework in which such conditions may be understood as states of homeostatic lock-in, where regulatory processes stabilise around maladaptive equilibria rather than returning to baseline. Using psoriasis as an illustrative example, the analysis examines how immune feedback, tissue conditioning, and systemic spillover can sustain inflammation in the absence of ongoing insult. The framework is presented as a falsifiable conceptual lens rather than a causal or therapeutic claim, and does not propose treatments, diagnostics, or clinical interventions.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18065699

Authors: Smith, John Richard, HATI (Human–AI Teaming Intelligence)

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7117407437

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