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Genetic applications in arthroplasty: A review

Year: 2025

Type: article

Abstract: ABSTRACT: Genetics is a burgeoning field within adult reconstructive surgery. Genome-wide sequencing has identified genetic variants found to be associated with not only the development of osteoarthritis but also arthroplasty-related complications, such as aseptic loosening, prosthetic joint infection, arthrofibrosis, and postoperative pain. Examples include newer technology, such as next-generation sequencing, in diagnosing culture-negative prosthetic joint infection. Genetics drives new therapeutic technologies, such as gene therapy, gene-editing, and bacteriophage treatment. Although still rare, a handful of phase 3 clinical trials of gene therapy for osteoarthritis have begun to demonstrate efficacy with low-risk profiles. As the field continues to grow, public and professional buy-in as well as cost present challenges.

Source: Bulletin of the Hospital for Joint Diseases/Bulletin of the Hospital for Joint Disease

DOI: 10.1097/bh9.0000000000000003

Authors: Jaclyn A. Konopka, Theodor Di Pauli von Treuheim, Lefko Charalambous, Ran Schwarzkopf, Joshua Rozell, Claudette Lajam

Institutions: NYU Langone Health, New York University Langone Orthopedic Hospital

Language: English

Topic: Orthopedic Infections and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7117429758

FWCI: 0.875

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Cited by: 1

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