Work

Evaluation of glutamic acid decarboxylase antibody in type 1 diabetes patients and its relationship with some biomarkers

Year: 2025

Type: article

Abstract: This work explored the differences in biochemical and immunologic indices between patients with type 1 diabetes mellitus (T1DM) and healthy controls. Random blood sugar (298.1 mg/dL) and HbA1c level (11.08%) in T1DM patients were significantly higher than those of participants with no diabetes, as depicted by the results. They also had significantly lower C-peptide levels, demonstrating a serious decline in b-cell function. Furthermore, GADA was significantly more frequent in patients with T1DM, again indicating a strong autoimmune response. There were only marginal differences in the GADA levels between different age groups, which were not significant. Conclusion: The levels of RBS, HbA1c, and GADA were increased in T1DM patients, while C-peptide was decreased, revealing the coexistence of metabolic as well as autoimmune disease. These markers are essential for the identification and monitoring of disease.

Source: Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research

DOI: 10.21608/jbaar.2025.474876

Authors: Ameer Wafaa Abdulameer, Alkhafaji Rafie Shakir, Hayder L.F. Al-Msaid

Institutions: Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, University of Kufa

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $120